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Trastuzumab Deruxtecan in Anti–Human Epidermal Growth Factor Receptor 2 Treatment–Naive Patients With Human Epidermal Growth Factor Receptor 2–Low Gastric or Gastroesophageal Junction Adenocarcinoma: Exploratory Cohort Results in a Phase II Trial

Her2-low is here to stay.  Expect further studies on Enhertu and Trodelvy on gastroesophageal Her-2 low patients.  Response rates were modest however, so temper expectations as single agent therapy.  I look forward to trials on future combination therapy.

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