This actually was mentioned during the Neil Love /FCS summit, it seems more tolerable than Afinitor, so is another option for relapsed refractory disease.
This study was done with and without obinutuzumab, both arms beat obinutuzumab and chlorambucil. There were more deaths in the obinutuzumab arm even though it was superior because of COVID, so it is immunosuppressive.
Patients were treated with thoracic and extrathoracic radiation to oligometastatic sites and it seems to help with improving survival, something to consider especially with SBRT now. Do our radiation oncologists have additional input?
This is another option for gastric cancer that is showing efficacy in non-HER-2 neutrophils, as Enhertu showed superiority in a recent study in the second line over taxol and cyramza (destiny gastric 4).
FOLFOX is the way to go … as no significant difference was observed in the long-term survival outcome between mFOLFOX6 with and without radiation and fluorouracil plus radiation.
Another trial with neoadjuvant immunotherapy showing improved results over chemotherapy alone. (12% higher PCR 48% vs 36%).
Combination beat monotherapy is another option for MSI patients. Is combo better then pembro?
The addition of danicopan (factor D inhibitor) reduced extravascular hemolysis, so reduced anemia on those patients compared to ravulizumab or eculizumab.
Ibrutinib delays disease progression for asymptomatic patients but has no overall survival (OS) benefit; hence, still watch and wait in those patients.
Improved progression-free survival (PFS), now we have osimertinib and ramucirumab, amivantamab and Lazertinib (PFS 24.8 vs 23 months but NOT head to head).
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